Study of vibrational excitation mechanisms of CO2 at high temperatures

Calculating vibrational excitation of CO2 for anharmonic coupling and normal mode at high temperatur

Study of vibrational excitation mechanisms of carbon dioxide at high temperatures

Vibrational relaxation models of carbon dioxide at high temperature

Estimating uncertainty of alcohol-attributable fractions for infectious and chronic diseases

Background: Alcohol is a major risk factor for burden of disease and injuries globally. This paper presents a systematic method to compute the 95% confidence intervals of alcohol-attributable fractions (AAFs) with exposure and risk relations stemming from different sources.Methods: The computation was based on previous work done on modelling drinking prevalence using the gamma distribution and the inherent properties of this distribution. The Monte Carlo approach was applied to derive the variance for each AAF by generating random sets of all the parameters. A large number of random samples were thus created for each AAF to estimate variances. The derivation of the distributions of the different parameters is presented as well as sensitivity analyses which give an estimation of the number of samples required to determine the variance with predetermined precision, and to determine which parameter had the most impact on the variance of the AAFs.Results: The analysis of the five Asian regions showed that 150 000 samples gave a sufficiently accurate estimation of the 95% confidence intervals for each disease. The relative risk functions accounted for most of the variance in the majority of cases.Conclusions: Within reasonable computation time, the method yielded very accurate values for variances of AAFs

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects

Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be cleaved by other proteases. Methodology/Principal Findings: To test the hypothesis that Bid is a central mediator of stress-induced apoptosis, we investigated the effects of a small molecule Bid inhibitor on stress-induced apoptosis, and generated HeLa cells deficient for Bid. Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and TRAIL-induced caspase activation and apoptosis, and significantly increased clonogenic survival. While Bid-deficient cells were equally sensitive to ER stress-induced apoptosis, they showed moderate, but significantly reduced levels of apoptosis, as well as increased clonogenic survival in response to the genotoxic drugs Etoposide, Oxaliplatin, and Doxorubicin. Similar effects were observed using the Bid inhibitor BI6C9. Interestingly, Bid-deficient cells were dramatically protected from apoptosis when subtoxic concentrations of ER stressors, Etoposide or Oxaliplatin were combined with subtoxic TRAIL concentrations. Conclusions/Significance: Our data demonstrate that Bid is central for death receptor-induced cell death and participates in anti-cancer drug-induced apoptosis in human cervical cancer HeLa cells. They also show that the synergistic effects of TRAIL in combination with either ER stressors or genotoxic anti-cancer drugs are nearly exclusively mediated via an increased activation of Bid-induced apoptosis signalling

Influence of Fertilizer Nitrogen and Sulfur on Production of Malting Barley

Studies in north-central Nebraska from 1975 through 1977: 1. Evaluated the malting barley production potential of the irrigated sandy soils of the region. 2. Measured the effect of application of N and S on yield and quality of barley grown for malting purposes. 3. Investigated the ability of N analysis of barley in the vegetative stage to predict protein content of grain at harvest. Data gathered lead to the following conclusions: 1. The potential for production of malting barley on irrigated sandy soils of north-central Nebraska is limited. 2. Yields increased with the application of fertilizer N throughout the study although response varied with site and variety. 3. Application of fertilizer S had no effect on yield throughout the study. 4. Application of N increased the protein content of all grain varieties studied by approximately 2 to 3 percent. 5. Analysis of plant material collected at the boot stage for N provided a reliable indication of the grain protein content

Low Mach Number Modeling of Type Ia Supernovae

We introduce a low Mach number equation set for the large-scale numerical simulation of carbon-oxygen white dwarfs experiencing a thermonuclear deflagration. Since most of the interesting physics in a Type Ia supernova transpires at Mach numbers from 0.01 to 0.1, such an approach enables both a considerable increase in accuracy and savings in computer time compared with frequently used compressible codes. Our equation set is derived from the fully compressible equations using low Mach number asymptotics, but without any restriction on the size of perturbations in density or temperature. Comparisons with simulations that use the fully compressible equations validate the low Mach number model in regimes where both are applicable. Comparisons to simulations based on the more traditional anelastic approximation also demonstrate the agreement of these models in the regime for which the anelastic approximation is valid. For low Mach number flows with potentially finite amplitude variations in density and temperature, the low Mach number model overcomes the limitations of each of the more traditional models and can serve as the basis for an accurate and efficient simulation tool.Comment: Accepted for publication in the Astrophysical Journal 31 pages, 5 figures (some figures degraded in quality to conserve space

Alcohol-attributable mortality in Switzerland in 2011--age-specific causes of death and impact of heavy versus non-heavy drinking.

BACKGROUND: Alcohol use causes high burden of disease and injury globally. Switzerland has a high consumption of alcohol, almost twice the global average. Alcohol-attributable deaths and years of life lost in Switzerland were estimated by age and sex for the year 2011. Additionally, the impact of heavy drinking (40+grams/day for women and 60+g/day for men) was estimated. METHODS: Alcohol consumption estimates were based on the Addiction Monitoring in Switzerland study and were adjusted to per capita consumption based on sales data. Mortality data were taken from the Swiss mortality register. Methodology of the Comparative Risk Assessment for alcohol was used to estimate alcohol-attributable fractions. RESULTS: Alcohol use caused 1,600 (95% CI: 1,472 - 1,728) net deaths (1,768 deaths caused, 168 deaths prevented) among 15 to 74 year olds, corresponding to 8.7% of all deaths (men: 1,181 deaths; women: 419 deaths). Overall, 42,627 years of life (9.7%, 95% CI: 40,245 - 45,008) were lost due to alcohol. Main causes of alcohol-attributable mortality were injuries at younger ages (15-34 years), with increasing age digestive diseases (mainly liver cirrhosis) and cancers (particularly breast cancers among women). The majority (62%) of all alcohol-attributable deaths was caused by chronic heavy drinking (men: 67%; women: 48 %). CONCLUSION: Alcohol is a major cause of premature mortality in Switzerland. Its impact, among young people mainly via injuries, among men mainly through heavy drinking, calls for a mix of preventive actions targeting chronic heavy drinking, binge drinking and mean consumption

X-Ray Pinhole Camera Spatial Resolution Using High Aspect Ratio LIGA Pinhole Apertures

X ray pinhole cameras are employed to provide the transverse profile of the electron beam from which the emittance, coupling and energy spread are calculated in the storage ring of Diamond Light Source. Tungsten blades separated by shims are commonly used to form the pinhole aperture. However, this approach introduces uncertainties regarding the aperture size. X ray lithography, electroplating and moulding, known as LIGA, has been used to provide thin screens with well defined and high aspect ratio pinhole apertures. Thus, the optimal aperture size given the beam spectrum can be used to improve the spatial resolution of the pinhole camera. Experimental results using a LIGA screen of different aperture sizes have been compared to SRW Python simulations over the 15 35 keV photon energy range. Good agreement has been demonstrated between the experimental and the simulation data. Challenges and considerations for this method are also presente